Browsing by Author "Silig, Yavuz"
Now showing items 1-19 of 19
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The Acute and Chronic Toxic Effect of Cypermethrin, Propetamphos, and Their Combinations in Rats
Eraslan, Gokhan; Kanbur, Murat; Silig, Yavuz; Karabacak, Mursel; Sarica, Zeynep Soyer; Sahin, Serap (WILEY-BLACKWELL, 2016)This study was aimed at determining the acute and chronic toxic effects of cypermethrin, propetamphos, and combined cypermethrin and propetamphos. Four groups, each comprising 10 animals, were established for the acute (a) ... -
The association between polymorphisms in glutathione S-transferase (GSTM1 and GSTT1) and lung cancer outcome
Gonlugur, Ugur; Pinarbasi, Hatice; Gonlugur, Tanseli Efeoglu; Silig, Yavuz (TAYLOR & FRANCIS INC, 2006)Background: Polymorphisms in the glutathione S-transferase (GST) family may be associated with increased risk of lung cancer, somatic changes in lung tumour tissue, and survival. We evaluated survival according to GST ... -
AXIN2 polymorphism and its association with prostate cancer in a Turkish population
Pinarbasi, Ergun; Gunes, Emine Gulsen; Pinarbasi, Hatice; Donmez, Gonca; Silig, Yavuz (HUMANA PRESS INC, 2011)Polymorphism of AXIN2, a component of Wnt signaling, has been shown to play a role in tumorigenesis and dysregulated in cancer cells. In order to find out if AXIN2 polymorphism is a risk factor for prostate cancer, we ... -
The Diagnostic Value of the Correlation between Serum Anti-p53 Antibody and Positron Emission Tomography Parameters in Lung Cancer
Hasbek, Zekiye; Dogan, Omer Tamer; San, Ismail; Yucel, Birsen; Seker, Mehmet Metin; Turgut, Bulent; Berk, Serdar; Silig, Yavuz (GALENOS YAYINCILIK, 2016)Objective: Mutations in the p53 gene are the most commonly observed genetic abnormalities in malignancies. The purpose of this study was to assess the diagnostic value of serum anti-p53 antibody (Ab) along with the correlation ... -
The effects of colostrum on some biochemical parameters in the experimental intoxication of rats with paracetamol
Karabacak, Mursel; Kanbur, Murat; Eraslan, Gokhan; Silig, Yavuz; Sarica, Zeynep Soyer; Tekeli, Muhammet Yasin; Tas, Ayca (SPRINGER HEIDELBERG, 2018)In the current study, the possible prophylactic and therapeutic effects of colostrum (COL) on acute organ injury caused by paracetamol (PAR) in rats were evaluated. Within the scope of this study, a 2-month-old male (150-200 ... -
An in vitro Study of Cytotoxic Activity of Euphorbia macroclada boiss on Mcf-7 Cells
Tas, Ayca; Sahin-Bolukbasi, Serap; Cevik, Esranur; Ozmen, Esma; Gumus, Erkan; Silig, Yavuz (ASSOC PHARMACEUTICAL TEACHERS INDIA, 2018)Objective: The study was aimed to evaluate the cytotoxic activity of acetone extract of leaves, flower and body of Euphorbia macroclada boiss on human breast cancer cell line (MCF-7). Material: The cells were plated at a ... -
Investigation of the association between the MDM2 T309G polymorphism and gastric cancer
Tas, Ayca; Atabey, Mustafa; Caglayan, Gulcin; Bostanci, Meric Emre; Bolukbasi, Serap Sahin; Topcu, Omer; Silig, Yavuz (SPANDIDOS PUBL LTD, 2017)Murine double minute clone 2 oncoprotein (MDM2) is a key component in the regulation of the tumour suppressor p53. The association between the MDM2 polymorphism and gastric cancer (GC) has been investigated in Turkish ... -
An investigation of the relationship between SULT1A1 Arg(213)His polymorphism and lung cancer susceptibility in a Turkish population
Arslan, Serdal; Silig, Yavuz; Pinarbasi, Hatice (WILEY-BLACKWELL, 2009)Human sulfotransferase 1A1 (SULT1A1), the most expressed isoform of the phenol SULT1 subfamily, is an important member of sulfotransferase superfamily. A transition, G to A at position 638, in SULT1A1 gene, results in ... -
Investigation of wound healing in rat lung tissues in the postpartum period
Karadayi, Sule; Sahin, Ekber; Nadir, Aydin; Tuncer, Ersin; Silig, Yavuz; Korkmaz, Ilhan; Tanzer, Fatos; Sezer, Hafize; Kaptanoglu, Melih (SPANDIDOS PUBL LTD, 2012)To assess the wound healing capabilities of damaged lung tissue in the postpartum period, we investigated the parameters related to wound healing in a rat model of lung damage. Rats were divided into six groups: IA, I B, ... -
Is there a relation between Murine double minute 2 T309G polymorphism and lung cancer risk in the Turkish population?
Yilmaz, Meral; Tas, Ayca; Kacan, Turgut; Sari, Musa; Silig, Yavuz (WALTER DE GRUYTER GMBH, 2017)Introduction: Association between Murine double minute 2 T309G polymorphism and lung cancer risk has been investigated in several populations, but results of these studies are inconsistent. We aimed to investigate the ... -
Manganese-superoxide dismutase (MnSOD) polymorphisms
Silig, Yavuz; Tas, Ayca; Pinarbasi, Hatice (WALTER DE GRUYTER GMBH, 2015)Objective: Manganese superoxide dismutase (MnSOD, SOD2), the only known superoxide scavenger in mitochondria, may be particularly important for antioxidant defense because mitochondria are the major sites for cellular ... -
Microsomal epoxide hydrolase polymorphisms
Pinarbasi, Hatice; Silig, Yavuz; Pinarbasi, Ergun (SPANDIDOS PUBL LTD, 2010)Microsomal epoxide hydrolase plays a dual role in the activation and detoxification of carcinogenic compounds. Two polymorphic sites have been described in exons 3 and 4 of the microsomal epoxide hydrolase gene that change ... -
Myeloperoxidase G-463A polymorphism and risk of lung and prostate cancer in a Turkish population
Arslan, Serdal; Pinarbasi, Hatice; Silig, Yavuz (SPANDIDOS PUBL LTD, 2011)Myeloperoxidase (M PO) is a phase I enzyme that can bioactivate many specific procarcinogens, including polycyclic aromatic hydrocarbons and aromatic amines. The MPO gene contains a common single nucleotide polymorphism, ... -
Role of SOD2 Ala16Val polymorphism in primary brain tumors
Tas, Ayca; Silig, Yavuz; Pinarbasi, Hatice; Gurelik, Mustafa (SPANDIDOS PUBL LTD, 2019)The present study aimed to investigate the possible association between the genetic polymorphism of the enzyme superoxide dismutase 2 (SOD2, also known as manganese-dependent SOD), Ala16Val (rs4880), and primary brain tumor ... -
Significant association between MDM2 T309G polymorphism and colorectal cancer
Atabey, Mustafa; Tas, Ayca; Sari, Ismail; Bostanci, Meric Emre; Topcu, Omer; Silig, Yavuz (IMPRIMATUR PUBLICATIONS, 2019)Purpose: The Murine double minute 2 (MDM2) gene plays a crucial role in regulating and suppressing the function of apoptotic pathway. We investigated the relationship between MDM2 gene SNP309 (T309G) (rs2279744) polymorphism ... -
Strong association between lung cancer and the AXIN2 polymorphism
Gunes, Emine Gulsen; Pinarbasi, Ergun; Pinarbasi, Hatice; Silig, Yavuz (SPANDIDOS PUBL LTD, 2009)Accumulated evidence suggests that alterations due to mutations or genetic polymorphisms in the AXIN2 tumor suppressor gene, a component of the Wnt signaling pathway, contributes to carcinogenesis. The effect of the AXIN2 ... -
Sulfotransferase 1A1 Arg(213)His polymorphism and prostate cancer risk
Arslan, Serdal; Silig, Yavuz; Pinarbasi, Hatice (SPANDIDOS PUBL LTD, 2011)Sulfotransferase 1A1 (SULT1A1) is a member of the sulfotransferase family that plays an important role in the biotransformation of numerous carcinogenic and mutagenic compounds through sulfation. A transition, G to A at ... -
Superoxide Dismutase 1 (SOD 1) A251G Polymorphism
Silig, Yavuz; Tas, Ayca; Sahin-Bolukbasi, Serap; Caglayan, Gulcin; Sari, Ismail (WALTER DE GRUYTER GMBH, 2017)Objective: A genetic polymorphism of SOD1 A251G(rs2070424) is in the 3rd intron region of the SOD gene. The aim of this study was to determine the frequencies of the polymorphisms of the SOD1 A251G in a Turkish population, ... -
The toxic effect of cypermethrin, amitraz and combinations of cypermethrin-amitraz in rats
Kanbur, Murat; Silig, Yavuz; Eraslan, Gokhan; Karabacak, Mursel; Sarica, Zeynep Soyer; Aahin, Serap (SPRINGER HEIDELBERG, 2016)In this study, the effects of cypermethrin (CYP), amitraz (AMT) and combined cypermethrin-amitraz (CYP-AMT) on some serum biochemical, oxidative stress and drug-metabolising parameters were investigated in male Wistar ...